Ryan Bonelli
Available

Forward-Deployed AI Engineer · AI Systems Operator

Ryan Bonelli

AI integration that compounds. Multi-model systems and autonomous agents, deployed across every department — engineered by the operator who has run the work, not adjacent to it.

Currently accepting engagements · 48-hour reply

Ryan Bonelli
Ryan BonelliHappy Valley, OR
4–6×
Productivity multiplication
25+
Years in operations
11
Platforms self-built
11
Departments covered

Services · The Practice

Inside the work,
not adjacent.

Most AI adoption looks the same: a tool on every desk, a pilot every quarter, nothing that compounds. The practice does the opposite — multi-model orchestration, autonomous agents, and workflow automation, deployed as one operating layer and engineered into the work your team already does.

The differentiator is reach. I've built and run companies across every department I now deploy into — so the AI lands inside the actual work, because I've done the actual work.

What changes

Speed of execution. Quality of output. Depth of decision-making. Throughput of the entire business.

Engagement model · Five phases

01 MapHow work actually moves

A structured review of how work moves through your business — by department, function, and hand-off. We surface where time is leaking, where quality is degrading, and where AI can carry real load.

02 PrioritizeThe few that compound

Not every workflow is worth automating. We isolate the few that compound — where AI delivers outsized leverage on speed, quality, or decision-making. Ranked by operational ROI, not theoretical capability.

03 BuildProduction, not pilots

Code-level engineering. Multi-model orchestration, autonomous agents, and workflow automation built into your existing stack. Production systems your team owns — not demos, not pilots, not vendor lock-in.

04 EnableCapability stays in-house

Your people are the multiplier. I train them on the methodology, the systems, and the operating discipline to run AI-augmented work at scale. The capability stays in-house when I leave. It has to.

05 CodifyInstitutional ownership

Documentation, governance, and operating standards so the gains compound. AI integration becomes institutional capability — not a single-person dependency, not a one-off project, not something that breaks when you leave the room.

Functional reach · Eleven departments

Sales Marketing Administration Sourcing Logistics Manufacturing Engineering Customer Comms Documentation Investor Relations Executive Ops

Strategy, engineering, deployment, and team enablement — one engagement, end-to-end. Selective by design.

Discuss an engagement

Build studio · Houtos Labs

Led by Ryan Bonelli

When the work needs more than one person, my team takes over. Houtos Labs is a senior-only build studio I lead — engineers and designers shipping custom software for operating companies, built end-to-end, handed off production-ready, owned by your team from day one.

Not an agency. Not a marketplace. A small team that builds the way operators want software built — opinionated, fast, accountable to the result. Available standalone, or alongside the AI integration practice when you need both.

01 · Build

Applications

Native iOS and Android, cross-platform mobile, desktop. MVP through production scale — designed for retention, engineered to last past the launch.

React Native · Swift · Kotlin · Tauri

02 · Platform

Advanced Web Platforms

Real-time data, complex state, enterprise architecture. SaaS products, customer portals, internal tools, operator dashboards — built to perform under real load, not just demo well.

React · Next.js · Node · Postgres · WebSocket

03 · Integrate

Systems Integration

Custom integrations across your existing stack — databases, CRMs, ERPs, payment rails, internal tooling. Making the systems that don't talk, talk.

REST · GraphQL · Webhooks · ETL · Cloud

Design, engineering, deployment, ongoing support — under one roof, by a team that ships. Available for full custom builds and longer-term partnerships.

Engage Houtos Labs

Selected Work

Platforms built
independently.

Designed, architected, and coded personally — outside my professional roles. Each built from scratch, no contractors, no agencies.

Kaizen trading engine Live

AI · Fintech · Quant · Web3

Kaizen

A financial quant desk built on a multi-intelligence trading system. Walk-forward strategy validation, information-coefficient analysis, on-chain execution with MEV and slippage protection, and a multi-agent decision layer across Base L2.

Python · Solidity · Base L2 · Multi-Agent · Chainlink kaizenxyz.xyz
Peregrine.Technology investor relations platform Live

AI · SaaS · Investor Relations · B2B

Peregrine.Technology

Portfolio company stakeholder dashboard and investor communications platform. AI-assisted update generation, automated reporting cadence, and a centralized layer for cross-portfolio communication — built to operationalize my own IR practice across PPS.

React · Node · LLM · Python · Postgres peregrine.technology
Opsona AI-native operations platform Live

AI · SaaS · Regulated Manufacturing

Opsona.ai

AI-native operations platform for regulated manufacturing — compliance automation, SOPs, training management, and quality systems for FDA-regulated facilities. Website and Phase One built independently.

React · Python · LLM · RAG · Node opsona.ai
Based Guardians Web3 gaming platform Live

Web3 · NFT · Base L2 · Gaming

Based Guardians

Full-scale Web3 gaming platform on Base L2 — play-to-earn mechanics, custom smart contracts, NFT minting engine, transactional marketplace, live data dashboards, and on-chain leaderboards. Built entirely from scratch.

Solidity · React · Base L2 · ERC-4337 · Node basedguardians.xyz
Decimal Engineered B2B platform In progress

E-commerce · AI · B2B · Manufacturing

Decimal Engineered

Custom B2B platform for precision process equipment — AI education layer, e-commerce marketplace, authenticated customer portal with live machine data dashboards. Built independently from the company I operate.

React · Python · LLM · Node · REST API decimal.supply
MRX Manufacturing platform Live

Manufacturing · B2B · Industrial · Oregon

MRX Manufacturing

Oregon-engineered precision manufacturing platform — high-density liquid cooling for AI data centers and semiconductor fabs, plus ASME-compliant process equipment for pharma, food, and defense. Custom storefront, capabilities matrix, and quote engine.

React · Node · Custom CMS mrxmfg.com
LabGear Supply storefront Live

E-commerce · B2B · Lab Supply · Scientific

LabGear Supply

B2B e-commerce platform serving processing labs with premium scientific consumables and equipment. Distribution partnerships with Huber, Heidolph, Julabo, Büchi, and Swagelok. Full storefront, inventory, and order management.

E-commerce · Inventory · Payments · Distribution labgear.supply

E-commerce · Retail · Distribution

Monster Gardens

One of the first large-scale e-commerce operations in its category — built from the ground up. Grew to multi-million dollar revenue across four countries, with a digital education channel that reached 85K subscribers.

E-commerce · ERP · CRM · YouTube monstergardens.com

In development & internal

Live · Internal Content Engine Python · LLM · RAG · Multi-Agent · Node Semi-autonomous platform for educational presentations and structured long-form content. Multi-model orchestration coordinates research, drafting, design, and review — compressing a 30–60 hour production cycle into 4–8 hours. Measured time reduction: 70–90% on real output. In production use
Dev GoldBUG / NiffLer Solidity · ERC-4337 · Python · Chainlink · Pyth Non-custodial fintech platform on Base L2. ERC-4337 account abstraction, multi-source oracle consensus, algorithmic trading engine, and real-asset accumulation mechanics. Self-architected. Active development
Dev · 20% EdifyEUD React · Node · LLM · RAG · Multi-Agent Educational platform under active development — structured learning experiences powered by multi-model AI, designed for self-directed learners and instructional workflows. Architecture, core learning engine, and content pipeline in place. edifyeud.com
Independent development stack

Contracts

ERC-4337 · ERC-721 · ERC-1155

Chains

Base L2 · Ethereum mainnet

Oracles

Chainlink · Pyth · Uniswap TWAP

Backend

Python · Node · REST · WebSocket

Frontend

React · Vanilla JS

AI

LLM · RAG · fine-tuning

Ops

GMP · cGMP · ASME/UL · P&L

Pharmaceutical Research

Advanced compound synthesis
toward clinical application.

Through Peregrine Precision Systems, I co-founded NatSyn (Naturally Synthetic Inc.) — a joint venture with the Magolan Laboratory at McMaster University. NatSyn synthesizes rare, naturally occurring plant-derived compounds that cannot be cost-effectively sourced from biomass at commercial scale.

Using patent-pending chemistry, the lab produces novel active pharmaceutical ingredients at clinical purity standards for the global research and pharmaceutical communities. Three compound programs are currently positioned for potential Phase I human clinical trials, developed in collaboration with academic and medical researchers.

3

Clinical trial candidates

Compound programs under active development with medical researchers, positioned for potential Phase I progression.

>99%

API synthesis purity

Achieved with patent-pending chemistry, meeting Active Pharmaceutical Ingredient grade standards.

100g

Single-day batch capacity

Scaled within months of launch. Multi-kilo commercial scale-up underway at the Oregon facility.

McMaster

University partner

Sponsored Research Contract with the Magolan Lab — the Boris Family Endowed Chair of Drug Discovery.

Ventures & Track Record

Companies
operated.

Day job: Chief Operating Officer across two active companies in advanced manufacturing and life sciences, and Co-Founder of Peregrine Precision Systems — a platform spanning process equipment, ingredient production, and pharmaceutical research.

Practice: hands-on AI engineering for operating companies. Multi-model orchestration, autonomous agents, and workflow automation — deployed as a single operating layer, owned by the team. I write code when needed. The real advantage is the operating method, and the operator who has run the work it gets deployed into.

3+
Companies founded
50+
Professionals hired
2
Pharma accreditations
2001
Career start
LocationHappy Valley, OR
For hireAI integration · Custom builds
StudioHoutos Labs
Current rolesCOO · Co-Founder
ResearchMcMaster · Magolan Lab
AdvisoryAI SaaS · Decentralized tech
Dev focusAI agents · Web3 · Quant
Team led8-person executive team
Contactryan_bonelli@yahoo.com

Now · Current roles

2019 – PresentPlatform holding

COO & Co-Founder — Peregrine Precision Systems

Decimal · NatSyn · Polar

Parent company overseeing Decimal, ingredient manufacturing operations, and NatSyn. Strategy, IP management, and commercialization across the portfolio — 8-person executive team, shared P&L with CEO.

2019 – PresentProcess equipment

Chief Operating Officer — Decimal Engineered Systems

Subsidiary of Peregrine Precision Systems

US-based manufacturer of certified, GMP-compliant process equipment serving pharmaceutical, food, and regulated industries. Full production lifecycle oversight — engineering through customer delivery — with a North American service organization.

ActivePharmaceutical R&D

Co-Founder — Naturally Synthetic (NatSyn)

Via PPS · Joint venture with McMaster University

Joint-venture research lab synthesizing novel APIs at pharmaceutical purity. Three programs approaching clinical trial candidacy.

ActiveIngredient manufacturing

Chief Operating Officer — Polar (PPS Division)

GMP ingredient manufacturing

GMP ingredient manufacturing for food and pharmaceutical applications. Contributed to significant production output increases and regulatory approvals including novel food designation in the EU.

EU novel food approval

ActiveFintech

Founder — GoldBUG

Independent venture · Base L2

Non-custodial architecture, algorithmic trading infrastructure, and real-asset accumulation in tokenized assets. Self-architected and developed.

2025 – PresentAdvisory

Commercialization Advisor — Opsona

AI for regulated manufacturing

Leading commercialization for AI-driven operations software — translating technical capabilities into market-ready offerings and go-to-market strategy.

Earlier · 2001 – 2025

2022 – 2025

Lead Advisor — Houtos Labs

Product strategy, commercialization, and ecosystem design for decentralized technology initiatives. Translated complex technical concepts into user-facing products and business models.

2016 – 2019

Chief Executive Officer — Holistic Research

Led a California-based research and production business from concept through commercial development. Managed design, engineering, construction, and investor relations across multiple project sites.

2013 – 2016

President — Commercial Supply Company

Led a commercial supply operation through a period of significant industry growth. Business development, key account management, and market positioning.

2010 – 2016

CEO & Co-Founder — Monster Gardens / SPW Inc.

Built two companies from scratch to multi-million dollar revenue. Four-country distribution, thousands of SKUs, ERP and CRM implementation at scale, and a digital education channel reaching 85K subscribers.

4 countries · 85K subscribers

2004 – 2010

Account Executive — American Brokers Conduit

Grew a regional wholesale lending territory from the ground up — 15 to 180+ active broker relationships in Northern California.

2001 – 2004

Real Estate Finance — Temple Inland Mortgage

Early-career foundation in financial analysis, portfolio evaluation, and structured lending.

Full CV

Over two decades leading companies across advanced manufacturing, regulated process technologies, pharmaceutical research, financial services, and technology. Available upon request — I'll respond promptly.

Request CV

Writing & Practice

Perspectives on
industry & technology.

Operations

GMP Compliance in Advanced Manufacturing: A Practical Framework

Drawing on operational experience across regulated equipment manufacturing and ingredient production — a practitioner's guide to building repeatable GMP-compliant systems at scale.

Request a copy

Technology

Non-Custodial DeFi Architecture: Building Without Counterparty Risk

An exploration of ERC-4337 Account Abstraction, oracle consensus design, and the architecture of autonomous financial systems that eliminate centralized key exposure.

Request a copy

Pharma R&D

Synthetic API Production: Scaling Rare Compounds from Bench to Commercial

Documenting the operational and scientific pathway from academic research partnership to pharmaceutical-grade API synthesis at commercial scale — lessons from NatSyn's launch.

Request a copy

These papers represent applied thinking from direct operational and development experience. Reach out to discuss any of the topics or to request copies.

Contact

Engage
directly.

For operators, founders, and investors with substantive work in AI integration, custom software, or operational transformation. Send a brief — every reply comes from me, not a gatekeeper.

Available · Typical reply within 48 hours · Happy Valley, OR